The Purines
نویسندگان
چکیده
منابع مشابه
Biosykthesis of the Purines
GAR transformylase, which is responsible for the incorporation of formate carbon into what becomes position 8 of the purine ring, has been completely separated from 5-amino-4-imidazolecarboxamide ribotide transformylase (3). The latter enzyme is responsible for the incorporation of formate carbon into position 2 of the purine ring. The requirement for folic acid compounds has been demonstrated ...
متن کاملBiosynthesis of the purines.
4-Amino-5-imidazolecarboxamide (l), an amine found to accumulate in bacterial systems poisoned either by sulfonamides (2, 3) or aminopterin (4), has been suggested as an intermediate of purine synthetic reactions (5, 6). Although the metabolic inertness of the carboxamide’ in certain bacterial systems (7, 8) led to the belief by some (8) that this compound was an aberrant product of metabolism ...
متن کاملTerpenyl-Purines from the Sea
Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis...
متن کاملPurines and sensory nerves.
P2X and P2Y nucleotide receptors are described on sensory neurons and their peripheral and central terminals in dorsal root, nodose, trigeminal, petrosal, retinal and enteric ganglia. Peripheral terminals are activated by ATP released from local cells by mechanical deformation, hypoxia or various local agents in the carotid body, lung, gut, bladder, inner ear, eye, nasal organ, taste buds, skin...
متن کاملUrinary purines in leukemia.
Urinary purine excretion has been determined for four normal subjects, for thirteen patients with different types of acute and chronic leukemia, and for one man with mycosis fungoides by means of paper chromatography. Differentiation between types of leukemia, based on punine excretion, was not conclusive. Increases in 1-methylhypoxanthine and 8-hydroxy-7-methylguanine in nearly all patients, a...
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ژورنال
عنوان ژورنال: Nature
سال: 1973
ISSN: 0028-0836,1476-4687
DOI: 10.1038/243550c0